SCIENTIFIC RESEARCH REFERENCES REGARDING EPIGENETICS
2023 Mar 30;15:56. doi: 10.1186/s13148-023-01468-y
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DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites
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This review highlights the current state of knowledge on significant relationship between DNA methylation and CVD in humans. An open-access database has been compiled of reported CpG methylation sites, genes and pathways that may play an important role in this relationship.
2. DNA methylation predicts adverse outcomes of coronary artery disease
Min Qin, Xiaoxue Tian, Qili Wu, Nature Communications volume 16, Article number: 11396 (2025) Cite this article
CONCLUSION: Adverse outcomes including myocardial infarction (MI) and stroke render coronary artery disease (CAD) a leading cause of death worldwide. DNA methylation markers may alert such adversity ahead of the events. We profiled DNA methylation of blood leukocytes in 933 Chinese CAD patients with up-to-13-year follow-up from three centers, identifying 70 differentially methylated sites (DMPs) associated with future death. These DMPs correlated with inflammation markers, left ventricular functions and high-density lipoprotein cholesterol, and impacted gene expression in immune response and cellular scenesence. Notably, cg25563198 and cg25114611 were discovered to regulate FKBP5, whose upregulation persisted during MI and stroke. Fkbp5 knockout in male mice partially rescued MI by reducing infarct size and improving heart function, confirming its critical function. Finally, our prognostic model of 10 methylation sites and 5 clinical features outperformed clinical models. Our study highlights the value of DNA methylation in predicting prognosis in CAD and provides tools for clinical translation.
3. Ultra-processed food intake and mortality in the USA: results from the Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994)
Hyunju Kim 1,2, Emily A Hu 2,3, Casey M Rebholz 2,3,*The Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994).
Conclusions
Higher frequency of ultra-processed food intake was associated with higher risk of all-cause mortality in a representative sample of US adults. More longitudinal studies with dietary data reflecting the modern food supply are needed to confirm our results.
To understand the impact of ultra-processed foods on American health, consider the following points:
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Ultra-processed foods are linked to various health issues, including obesity, diabetes, and heart disease.
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Studies suggest that high consumption of these foods correlates with increased mortality rates.
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The number of deaths attributed to diet-related diseases may exceed those from past world wars.
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Poor diet is a leading risk factor for chronic diseases in the U.S., surpassing many other causes of death.
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Public health experts advocate for reducing ultra-processed food intake to improve overall health outcomes.
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Ongoing research continues to explore the long-term effects of ultra-processed foods on mortality.